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Ozturk M: p53 mutation in hepatocellular carcinoma after aflatoxin exposure. In this context, Schetinin [87] has developed an algorithm to classify artifacts and normal segments in clinical EEGs. PinotF,GrantDF,BeethamJK,ParkerAG,BorhanB,LandtS,JonesADandHammockBD 1995) Molecular and biochemical evidence for the involvement of the Asp-333- His-523 pair in the catalytic mechanism of soluble epoxide hydrolase.

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MGluR PL DAG PIP2 PKC PLC PLA2 Arachidonic acid Cyclo- oxygenases Lipo- oxygenases Ischemia Glutamate release NMDA-R GluR Reviws Nitric oxide synthase NO Ca2 Na NaCa2 Exchanger G IP3 Death VSCC Na Endoplasmic reticulum O2 Lipid peroxidation products Destabilization of cell membranes O2 H2O2 Eicosanoids Peroxynitrite Impaired energy production FIGURE 32-5 Mechanisms contributing to neuronal injury during ischemiareperfusion.

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